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ChemicalBook > CAS DataBase List > ALPHA-(-)-THUJONE

ALPHA-(-)-THUJONE

Uses
Product Name
ALPHA-(-)-THUJONE
CAS No.
546-80-5
Chemical Name
ALPHA-(-)-THUJONE
Synonyms
α-Thujone;a-Thujone;Thujon;Nsc93742;l-Thujone;Tanacetone;thujan-3-one;(?)-α-Thujone;(-)-α-thujone;6-Ketosabinane
CBNumber
CB2418953
Molecular Formula
C10H16O
Formula Weight
152.23
MOL File
546-80-5.mol
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ALPHA-(-)-THUJONE Property

Melting point:
181℃
alpha 
D20 -19.2°
Boiling point:
84-86 °C17 mm Hg(lit.)
Density 
0.914 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.450
Flash point:
148 °F
storage temp. 
2-8°C
solubility 
DMSO : 100 mg/mL (656.90 mM; Need ultrasonic)
form 
Oil
color 
Colourless
Odor
at 10.00 % in dipropylene glycol. cedarleaf thujonic
Odor Type
thujonic
optical activity
[α]20/D 19.0±2.0°, neat
BRN 
4660369
LogP
2.044 (est)
CAS DataBase Reference
546-80-5
EPA Substance Registry System
Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, (1S,4R,5R)- (546-80-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
23-26-36/37/39-45
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
RTECS 
XO9625000
F 
23
HS Code 
2914290090
Toxicity
LD50 s.c. in mice: 87.5 mg/kg (Rice, Wilson)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
89231
Product name
(?)-α-Thujone
Purity
≥96.0% (GC)
Packaging
1ml
Price
$92.9
Updated
2024/03/01
Sigma-Aldrich
Product number
89231
Product name
(?)-α-Thujone
Purity
≥96.0% (GC)
Packaging
5ml
Price
$351
Updated
2024/03/01
TRC
Product number
T006230
Product name
α-Thujone
Packaging
0.5ml
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
OR938655
Product name
(1S,4R,5R)-1-Isopropyl-4-methyl-bicyclo[3.1.0]hexan-3-one
Purity
95%
Packaging
1g
Price
$232
Updated
2021/12/16
Chem-Impex
Product number
41379
Product name
(1S,4R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one,96%(GC)
Purity
96%(GC)
Packaging
5ML
Price
$276.64
Updated
2021/12/16
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ALPHA-(-)-THUJONE Chemical Properties,Usage,Production

Uses

α-Thujone is a GABA modulator and a genotoxic compound found in plants used in traditional medicines in developing countries.

Chemical Properties

Colorless liquid. Insoluble in water; soluble in alcohol. Combustible.

Uses

Solvent.

Uses

α-Thujone is a GABA modulator and a genotoxic compound found in plants used in traditional medicines in developing countries.

Definition

ChEBI: The (1S,4R,5R)-stereoisomer of alpha-thujone.

General Description

(-)-α-Thujone, a monoterpene ketone found in the essential oil of Thuja occidentalis, shows potent antitumorigenic effect.

Hazard

Toxic by ingestion.

Biochem/physiol Actions

GABAA receptor antagonist.

Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. Serious physiological consequences from abuse of absinthe (mainly in France) led to its abolition in 1915. Wormwood is still used in concentrations of less than 10 ppm in flavored wines. Thujone at 30 mg/kg causes convulsions associated with lesions of the cerebral cortex. Little is known of thujone metabolism. Both forms occur in wormwood oil, oak moss. The a form is major constituent of cedar leaf oil or oil of thuja, sage. The p form occurs in tansy, yarrow. When heated to decomposition it emits acrid smoke and irritating fumes.

ALPHA-(-)-THUJONE Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-(-)-THUJONE Suppliers

China 57 Germany 3 India 1 Switzerland 1 Ukraine 1 United Kingdom 1 United States 13 Global 77
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from ALPHA-(-)-THUJONE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
()-α-Thujone 546-80-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

546-80-5, ALPHA-(-)-THUJONERelated Search:

ETHYLCYCLOPROPANE 1-ETHYL-4-METHYLCYCLOHEXANE 2-METHYL-5-HEPTANONE 2-Methylhexane 3-Hexanone 3-METHYLHEPTANE ALPHA-(-)-THUJONE 2-METHYL-3-PENTANONE 2,3-DIMETHYLHEXANE 3-ETHYLHEXANE 3,3-DIMETHYLHEXANE 2,4-DIMETHYLHEPTANE 2,3-Dimethylbutane Ethylcyclohexane TRANS-1,4-DIMETHYLCYCLOHEXANE 3,3-Dimethylpentane 4-Methyl-2-pentanone 3-METHYLHEXANE

  • (1s,4r,5r)-(-)-3-thujanon
  • 3-Thujanone, (-)-
  • 3-Thujanone, (1S,4R,5R)-(-)-
  • 4-methyl-1-(1-methylethyl)-,[1S-(1.alpha.,4.alpha.,5.alpha.)]-Bicyclo[3.1.0]hexan-3-one
  • 4-Methyl-1-(1-methylethyl)bicyclo[3.1.0]hexan-3-one
  • 6-Ketosabinane
  • THUJONE, ALPHA-(-)-
  • (-)-ALPHA-THUJONE
  • ALPHA-(-)-THUJONE
  • (-)-3-Isothujone
  • (-)-3-thujanon
  • a-Thujone
  • (1S,4R,5R)-4-METHYL-1-(PROPAN-2-YL)BICYCLO[3.1.0]HEXAN-3-ONE
  • bicyclo(3.1.0)hexan-3-one,4-methyl-1-(1-methylethyl)-,(1s-1-alpha,4-alpha,5
  • Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, [1S-(1alpha,4alpha,5alpha)]-
  • bicyclo[3.1.0]hexan-3-one,4-methyl-1-(1-methylethyl)-,[1s-(1alpha,4alpha,5
  • Isothujone, (-)-
  • l-Thujone
  • Tanacetone
  • thujan-3-one
  • Thujon
  • [1S]-4-Methyl-1α-[1-methylethyl] bicyclo[3.1.0]hexan-3-one
  • Bicyclo3.1.0hexan-3-one, 4-methyl-1-(1-methylethyl)-, (1S,4R,5R)-
  • Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, [1S-(1α,4α,5α)]-
  • A-(-)-THUJONE WITH GC
  • Nsc93742
  • ()-α-Thujone,(1S,4R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one
  • (1S,4R,5R)- 3-Thujanone
  • (-)-alpha-Thujone >=96.0% (GC)
  • (1S,4R)-1-ISOPROPYL-4-METHYLBICYCLO[3.1.0]HEXAN-3-ONE
  • α-Thujone
  • (?)-α-Thujone
  • (-)-α-thujone
  • pro-apoptotic,anti-invasive,α Thujone,Monoterpene,oxidative,antinociceptive,Gamma-aminobutyric acid Receptor,Apoptosis,Inhibitor,BBB,γ-Aminobutyric acid Receptor,inhibit,Reactive Oxygen Species,Autophagy,GABA Receptor,ROS,Parasite,αThujone,anthelmintic,anti-tumor,α-Thujone,insecticidal,stress
  • (1S,4R,5R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one
  • 546-80-5
  • Cell Signaling and Neuroscience
  • C10
  • Cell Biology
  • Carbonyl Compounds
  • BioChemical
  • Building Blocks
  • GABA and Glycine Receptor Modulators
  • Ketones
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Organic Building Blocks
  • Organics